|
|
The NRR Graphics Library is an educational resource that provides slides, pictures of structures, mechanisms and overviews of the action of nuclear receptors. We hope that its continued development be of service to those who teach higher level courses as well as to those who need a few starters for preparing talks or presentations. Please send us your feedback and your artistic contributions!
INSTRUCTIONS FOR LIBRARY USERS: all users are expected to cite the source of art work and the artist, and to make original contributions. Slides are copyrighted by the original authors. Permission to reproduce/modify art work is given as long as credit is given. Download files only if you agree to the above requirements.
|
Steroid Receptors: structural comparison |
|
|
|
 |
|
Download TIF file (1,200K) |
|
|
|
|
|
Coactivator/Heat Shock Protein Interaction |
|
|
|
|
|
Download TIF file (1,200K) |
|
|
|
|
|
Activation of steroid receptors |
|
|
|
 |
|
Download TIF file (1,200K) |
|
|
|
|
|
Transcriptional activation by steroid receptors |
|
|
|
 |
|
Download TIF file (1,200K) |
|
|
|
|
|
Synergism between steroid receptors |
|
|
|
 |
|
Download TIF file (1,200K) |
|
|
|
|
|
Steroid structures |
|
|
|
 |
|
Orthographic view of nuclear receptor
with H12 "below". |
|
|
|
 |
|
The volume defined by H12, H11, H5 and H3 provides an opening into the ligand binding domain. Polar regions on H5 and H3 near "loop" assist in docking the polar regions of the ligand |
|
|
Orthographic view of a steroid (green contour) approaching the LB cavity |
|
|
|
 |
|
Orthographic view of nuclear receptor
(MR) |
|
|
|
 |
|
The closing of H12 results in the predominantly lipophilic ligand being surrounded by the hydrophobic interior of the receptor |
|
